Title: Effectiveness of mesenchymal stem cells in diabetic nephropathy animal model: Insights into amyloidosis clearance

Abstract:Background: Diabetic nephropathy (DN) refers to the deterioration of kidney function seen in chronic diabetes mellitus. The exact pathway of MSCs-based treatment in DN and how they modulate the pathogenesis progression is not fully understood. The current study aimed to study the effect of MSCs in DN animal model. Materials and methods: Rats were divided into DN group, which were given a single intraperitoneal injection of 60 mg/kg streptozotocin (STZ) and MSCs treated group, which were given a single-dose of MSCs (106cells) intravenously per rat. B-cell lymphoma 2 (Bcl-2) and organic cation transporter 1 (Oct1) gene expression were assessed in the injured kidneys after 8 weeks and histopathological assay was performed.Results: STZ group exhibited necrosis, pyknosis cytoplasmic vaculation, enlarged glomeruli obliterated filtration space and tubular lumen. Besides, fibrosis, infiltration of inflammatory cells and amyloid casts were observed peri and intra tubular. While, MSCs treated group showed absence of amyloid deposits and scanty collagen fibers in the capsular wall, peritubular and intraglomerular capillaries. Bcl-2 and Oct1 relative mRNA expressions were significantly up-regulated in MSCs treated diabetic group with respect to STZ group. Conclusion: In DN animal model, our data highlighted the contribution of MSCs in improving fibrosis and apoptosis. As well as their ability in clearing amyloid deposits, that may provide a standpoint toward the candidacy of MSCs in autophagy-enhancing.




Title: Intervention to osteoarthritis by utilizing natural resources available in Sri Lanka: A systematic review

Abstract:Osteoarthritis (OA) is a degenerative, age related joint disease and there is still no hope for a permanent cure. However, non-steroid anti-inflammatory drugs are prescribed to relieve pain. Nevertheless, these synthetic medications cause various side effects including gastritis, gastric ulcer and even renal failure on prolong and irrational usage. In contrast, Traditional Medical Practitioners are treating patients with OA for thousands of years with safe and effective herbs. This study was aim to identify the evident based herbal interventions (internal and external) to disseminate effective and safe the herbal practice to improve the condition of OA. The PubMed advanced and google scholars were searched to filter the articles. The keywords such as, ‘Botanical name of the herb’ OR ‘Common name’ with the keyword ‘osteoarthritis’ were used to filter articles up to 2019. Fifty-nine articles were filtered and 34 were excluded which contained duplicated experimental data or not directly relate to this study. This review exhibits the fact that some simple and easily available herbs provide satisfactory relief to the patients with least or no side effects.




Title: Molecular Detection of Some Virulence and Antibiotic Resistance Genes in Staphylococcus aureus Strains Isolated from Bovine Mastitis in Maysan Province

Abstract:Staphylococcus aureusone of the most important pathogens involved in bovine mastitis. The aim of this study was to determine the virulence and resistance gene profiles of 26 Staph. aureusisolatedfrom bovine mastitis milk in A-Amarah City, Maysan, Iraq. The presence of 4 virulence genes (tst,sirB, icaA, and hlg) that encoding for Toxic shock syndrome toxin, Siderophore compound transporter permease protein, Polysaccharide Intracellular adhesion, and Gama-hemolysin respectively, and 2 resistant genes (mecAand femA) that encoding for Methicillin resistance wereinvestigated by PCR. The occurrence of sirBand femAgenes (100%) was found to be common. The frequency of other genes was three (11.53%) of isolate expressed the mecAgene, four (15.38%) hlggene, seven (26.92%) tstgene and 24 (92.30%) had icaA. The results indicate the variation in the presence of virulence genes in Staphylococcus aureus isolates that are able to cause mastitis in cowsand PCR assays canbe used as rapid diagnostic tools to detect the virulence factors and antimicrobial susceptibility testing of S. aureusthat help in the detection of the severity of the infection.




Title: DEMOGRAPHIC POTENTIAL OF THE DEVELOPMENT OF SMALL SETTLEMENTS IN DECENTRALIZATION CONDITIONS

Abstract:It has been analyzed the demographic development of the population of small rural settlements of Transcarpathian region over the last 30 years in the given article. Much attention is paid to the study of the key problems that determine the processes of population, in particular, the trends which characterize population dynamics, natural population growth, changes in the gender-age structure of rural residents.




Title: ARTIFICIAL INTELLIGENCE AND EDUCATION Challenges and disadvantages for the teacher

Abstract:What is the teachers\' perception about the application of artificial intelligence and robotics in the teaching-learning processes?\nOther research questions? What are the challenges of the application of robotics and artificial intelligence in education?\nWhat are the disadvantages of the application of robotics and artificial intelligence in education?




Title: Iron Replacement Therapy in HCV infected ESRD Patients on Hemodialysis, in need or not in need?

Abstract:End-stage renal diseases ESRD needs dialysis is a global problem. Hepatitis C virus (HCV) infections among those patients represent a major challenge, especially with the high prevalence in Egypt. Iron overload is considerably seen in hemodialysis cases with chronic HCV, which will emphasize the progress of fibrosis and cirrhosis and possibly increase the risk of liver cancer in the general population. This study is designed to assess the iron parameter in ESRD on hemodialysis that was chronically infected with HCV to assess that if they in need of iron replacement therapy or not.




Title: PLACE OF SECURITY IN THE STATE GOVERNANCE SYSTEM: LAW APPROACH

Abstract:_The article deals with the problems of theoretical and applied aspects of state guard in the system of state governance in Ukraine. The study of the genesis of the emergence and establishment of state concludes that the institution of state leaders\' guard has appeared since the formation of the state, the emergence of state leaders and the emergence of contradictions between them. It is substantiated that in the context of reforms implemented in Ukraine, the modern security service of state authorities and officials has been established. It is concluded that the state guard is carried out under the statutory tasks directly in the sphere of state security and in order to ensure state security, and therefore, in the context of the activity of the Department of State Guard of Ukraine (hereinafter DSGU), the necessity of coercive measures application for the DSGU is wider and may concern either the offenders as provided for law enforcement agencies, or other persons in the interests of state protection of public authorities and officials.




Title: TOOLS OF SMALL BUSINESS DEVELOPMENT IN THE MOUNTAINOUS REGIONS OF THE CARPATHIAN REGION OF UKRAINE

Abstract:Research background: Mountain areas, considering the objective reasons for the limited transport accessibility and types of economic activities, insufficiently developed areas of employment and the social welfare system, remoteness from areas of intensive economic growth, business activity accumulation centers, capital and investment, intellectual staff and information flows, used to have low level of investment attractiveness, financial and economic development and quality of the social sphere. As a result, of these and other circumstances, the level of external labor migration significantly increases. This is the condition to use the economic methods of influence, among which one of the most effective is the method of stimulating of small business development. Purpose of the article: The aim of the article is to develop means to stimulate the development of small business as an effective economic method of external labor migration control in the mountainous areas of the Carpathian region of Ukraine. Methods: In the process of research, general scientific and special methods were used: synthesis and system analysis; statistical, economic and comparative analysis, strategic management, analytical and forecast calculations. Findings & Value added: The article analyzes the potential and state of the socio-economic development of mountain areas of the Carpathian region of Ukraine; the characteristics of the negative aspects of the development of small business in the state mountainous regions are given and the reasons for their occurrence. Investigated and graphically depicted the structure of the types of economic activity of mountain areas and identified the most promising areas of development and improving the efficiency of the small business. Given are the target landmark of the small business development policy, methods and measures that should be implemented in terms of improving the legal regulation of state support for the development of small business in mountain regions.




Title: PLANNING BASED ON CRISIS RESPONSE CAPABILITIES THAT THREATEN UKRAINE'S NATIONAL SECURITY

Abstract:The research, based on scientific and practical views, proposes the development of basic approaches to planning the activities of military formations and law enforcement agencies, based on the crisis response capabilities that threaten Ukraine\'s national security and that arise, including in the northern territories.




Title: CO Inhalation Inhibits Inflammation and T Cell Proliferation in Antibody-Induced Arthritis by IL-2 Signaling

Abstract:Background. To investigate the protective effect of carbon monoxide (CO), a potent regulator plays an ubiquitous role in down-regulation of acute inflammation, in the mice induced with collagen antibody-induced arthritis (CAIA).\nMethods. BALB/c mice were housed in separate chambers, one in room air and the other in an environment with a CO concentration of 250 parts per million. CO was administered 3 days before collagen antibody injection and continued until the mice were sacrificed. Clinical manifestations and histopathological changes in these mice were examined in a blinded manner. Total splenocytes from both groups were harvested for T cell proliferation. \nResults. In mice injected with the antibody, arthritic symptoms developed and culminated 7 to 10 days after injection. Disease severity was comparatively lower in the CO-treated group. IL-1β in CO-treated mice was markedly downregulated at the RNA and protein levels relative to the control group. T cell proliferation and IL-2 production were much lower in CO-treated mice. The CO-mediated inhibition of T cell proliferation was reversed by IL-2 administration, and CO pretreatment suppressed the production of IL-2 in splenocytes.\nConclusions. CO mediated significant anti-inflammatory effects and protected mice from CAIA. CO-mediated inhibition of cytokine secretion and T cell proliferation which occurs by IL2 signaling contributes to this protective effect.