The study of the impact of market orientation on the performance of Vietnamese startups was conducted based on the collection of survey data from 271 startups in Hanoi that were established in the period 2016 - 2018. Data collection was carried out from November 2019 to May 2020. Collected data was processed on SPSS20 software and estimated by linear regression method count. In this study, the authors consider the impact of factors in market orientation including (1) competitor orientation; (2) customer orientation; (3) the inter-functional coordination orientation and startup characteristics such as seniority, how field of activity affect startup performance. On that basis, the study proposes a number of suggestions to lead to the success of start-ups in Hanoi in particular and in Vietnam in general.

Background: Prolactin is a protein hormone, as well as a cytokine, which is synthesized and secreted from specialized cells of the anterior pituitary gland, named lactotrophs. as well as the fact that PRL is synthesized in many extrapituitary tissues. Among these sites of PRL synthesis are cells of the immune system, such as macrophages, natural killers, and T- and B-lymphocytes. Aim: This study aimed to demonstrate the histological and immunohistochemical alterations of the thymic gland T- cells in hyperprolactinemic adult male mice for different durations. Experimental design: Fifty mice were divided into five groups; group I: control mice, groups II, III, IV and V: were injected i.p. with metoclopramide for different durations 2, 4, 7 and 10 weeks, respectively. Results: A highly significant hyperprolactinemia and gradual significant increase in the body weight of mice groups II, III, IV and V was recorded. hyperprolactinemia mice group II for 2 weeks showed slight histological alterations in mice thymus tissues. hyperprolactinemia mice group III for 4 weeks illustrated a marked severe thymic involution .While hyperprolactinemia mice groups IV and V for 7 and 10 weeks illustrated clearly histological changes in the thymic tissues and their change were a time dependent. IHC study expressed intense immunoreactivity to CD4+/ CD8+ T-cells (helper and cytotoxic T cells, respectively) in the thymus tissue of control group (I) while in all hyperprolactinemia mice groups (II-V), CD4+/ CD8+ T-cells immunostain were markedly reduced. In conclusion, the present study revealed that HPRL lead to histological alterations in the thymus glands that were time- dependent, and subsequently lead to highly significant decrease in CD4+/ CD8+ T-cells. Therefore, metoclopramide should not be used for long duration, and must be used with caution as a therapy.

Antioxidant and inhibition of premature skin ageing activities of medicinal plants, in addition to varying degree of health benefits have received global recognition in recent times. The present study investigated the quantification of phytochemicals in the root, leaf, stem, seed, seed plus leaf (SK) of Cannabis sativa. The total antioxidant capacities of the plant extracts in hexane, pet-ether, ethyl acetate, methanol, butanol and water as well as their anti-lipid peroxidation (LPO) and tyrosinase (TYR) inhibitory activities were also investigated in an in-vitro system. The class of compounds therein contained in the respective plant extracts were investigated using assays of phenolics, flavonoid, flavonol and flavanol, while the total antioxidant capacities were determined through evaluation of trolox equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant potential (FRAP) assays. The outcome of this study showed that leaf contained highest flavonoids (532 ± 0.92 mg QE/g), phenolics (264 ± 8.73 mg GAE/g), flavanol (144 ± 2.70 mg CE/g) and flavonol (102 ± 3.78 mg QE/g). Aqueous extract of the leaf was found to contain highest FRAP of 1589 ± 20.4 μM AAE/g greater than the commercial antioxidant Epigallocatechin gallate (EGCG) of 1429 ± 0.82 μM AAE/g. The SK has the highest TEAC of 3172 ± 1.38 μM TE/g also greater than EGCG 2932 ± 9.97 μM TE/g. The seed extract of hexane has the highest LPO value of 89.1 ± 1.55 mg/mL, while the leaf extract of methanol has the highest TYR value of 82.2 ± 4.77 mg/mL. The results showed that the plant extracts can be used to reduce oxidative stress as well as inhibiting deleterious effect of skin enzyme responsible for the formation of pigments on the surface of the skin as well as perishable agricultural products.

Nowadays, all companies are looking for ways to ensure that the products they manufacture are of the highest quality and that they meet all expectations of customers, thus to increase their satisfaction. It should be noticed however that the business environment, customer expectations, and the products of competitors are changing. Furthermore, production technologies and machines are becoming obsolete. It is therefore necessary to seek new solutions and improve what is done. To achieve this goal, various types of quality management or improvement tools can be used, e.g. the 8D Report. The aim of this paper was to analyze the production problems occurring during the production of window slides with use of the 8D Report in a company producing stamped metal parts for the automotive and home appliance industries. This analysis was carried out based on complaints submitted by the main business partner. Once the main cause of the problem was identified, permanent corrective actions were planned and implemented according to the 8D Report, which helped also to reduce the likelihood of recurrence of this and similar problems. The case studied demonstrated that combination of the knowledge and experience of the team, the application of modern quality tools offers concrete and measurable effects and allows to solve problems, which before the preparation of the Ishikawa diagram, the Pareto chart, and the 8D Report were considered impossible to solve by the employees of the enterprise studied.