In conservation processes, the application of low temperatures has been recognised as a reliable treatment for the preservation of food. In this work, the thermal denaturation behaviour of the main proteins of raw, thawed and vacuum freeze-dried pork meat was analysed by modulated differential scanning calorimetry (MDSC). Meat protein extracts (myosin, actin and collagen) at 48 h post-slaughter were used as a reference. Among the changes observed, the denaturation temperatures of the main meat proteins did not vary significantly (P < 0.05). Structural changes were observed in the values of reversible Cp. Myosin denatures in the interval between 53 to 55 °C, actin between 76 and 79 °C, and the sarcoplasmic proteins and collagen between 63 and 66 °C, with higher enthalpy and maximum transition temperatures for collagen and actin in freeze-dried samples with a greater activation energy for myosin and collagen denaturation affected by the ice crystal formation in the slow freezing process.

Purpose\nProstate cancer is one of the leading malignancies affecting human male population worldwide. In this study, we identified differentially expressed genes, microRNAs (miRNAs) using large number of publically available heterogeneous datasets generated using high-throughput sequencing (NGS) technologies from prostate cancer and normal tissues. Targets of selected miRNAs were predicted using state of the art target prediction methods.\n\nMethods\nDifferential expression analysis was performed on The Cancer Genome Atlas (TCGA) Level 3 gene and miRNA expression datasets to identify differentially expressed, up and down-regulated genes and miRNAs in prostate cancer. Later inversely expressing target DEGs of 10 highly up and down-regulated miRNAs (DEMirs) were predicted using target prediction methods. Regulatory networks summarizing the regulatory links among the DEMirs and DEGs were created using Cytoscape.\n\nResults\nExpression analysis results led to identification of 844 up-regulated and 1123 down-regulated genes in prostate cancer while 101 up and, 30 down-regulated miRNAs in prostate cancerous tissues as compared to normal cells. These highly up regulated gene and, miRNAs can act as non-invasive biomarkers for prostate cancer detection. Gene Ontology (GO) and KEGG pathway enrichment analysis showed highly up-regulated genes in prostate cancer were involved in biological process associated with cell division. Highly up-regulated miRNAs in prostate cancer miR-483-3p, miR-483-5p etc. were found to be targeting tumor, metastasis suppressor genes.\n\nConclusion\nWe identified a molecular expression signature and pathway regulatory mechanisms in prostate cancer with potential diagnostic and therapeutic value. These findings may extend our understanding of the molecular mechanisms underlying prostate cancer and help prevent, diagnose, treatment of the disease.

Today, entrepreneurial skills are considered as the appropriate strategy for the expanding of productivity and overall development of any organization. Some scholars believe that the entrepreneurial skills, promote efficiency in different levels in organizations. The aim of this study was to investigate the relationship between organizational justice and organizational commitment with entrepreneurial skills in Urmia industrial Estate’s Companies. The results showed that there is a significant relationship between procedural, distributive and interactional components of organizational justice and affective, normative and continuance dimensions of organizational commitment with entrepreneurial skills. Regression analysis also showed that procedural and distributive components of organizational justice are better predictor for entrepreneurial skills and affective and continuance dimensions of organizational commitment are better predictor for entrepreneurial skills than others. The results of this research can be significant and useful for the owners of industries, firms, small and medium businesses, economic planners and managers.

Tunnel-form buildings are considered to be a type of high seismic safety building. Although this structural system has an important seismic advantage, it also has some disadvantages, especially in acoustic and thermal comfort. In this study, experimental studies have been conducted on reinforced concrete tunnel form members such as shear walls and slabs produced with plastic material having circular sections. In this scope, research has been performed on the feasibility of using plastic balls with 6 cm diameter in reinforced concrete systems. Reinforced concrete members have been produced with and without balls to analyze the structural behavior under static and quasi-static loading and to investigate the thermal performance and sound absorption behavior of the members. In the study, structural parameters have been determined for reinforced concrete members such as slabs and shear walls produced with and without balls to discover the feasibility of the research and discuss the findings comparatively. The results obtained from the experimental studies show that plastic balls used in reinforced concrete with suitable positions do not significantly decrease strength but improve the thermal and acoustic features.